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Phototherapy
Joklík, Vojtěch ; Škoda, Jan (referee) ; Štěpánek, Jaroslav (advisor)
This thesis describes relationship between human body and light. It is focused on perception of light with human eye, skin and their reaction to incident light and its intensity. Then it contains short description of Icterus Neonatorum (yellow-gum), Constitutional Dermatitis, Lepriasis and their treatment. It is followed by description of various sources of light, their use in medicine and reaction of body to them. This work includes measurements and evaluation of five sources of light.
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Quality of life in vitiligo patients
Stoklasová, Daniela ; Mareš, Jiří (advisor) ; Kutnohorská, Jana (referee)
Author: Daniela Stoklasová Institution: Department of non-medical studies Faculty od Medicine in Hradec Králové Title: Quality of life in vitiligo patients Supervisor: prof. PhDr. Jiří Mareš, CSc. Number of pages: 106 Year of defense: 2022 Keywords: vitiligo, quality of life, skin, multifactorial disease, nursing care The bachelor's thesis deals with the quality of life of patients with vitiligo. The theoretical part deals with the anatomy and function of the skin. Furthermore, the problems of vitiligo, the causes of this disease, the clinical picture, diagnosis, treatment, similar diseases and autoimmune diseases associated with vitiligo are explained. It also deals with nursing care for these patients and their self-care. Lastly, it clarifies the concept of quality of life, its history, how we generally evaluate quality of life and how we can evaluate it in patients with vitiligo, and also what effect this disease has on the patient's quality of life. The empirical part describes the results of quantitative research, which took place in 52 patients using the Czech version of the VitiQoL questionnaire, which was translated into Czech with the consent of foreign authors. Besides the overall quality of life, this bachelor's thesis focuses on specific areas of quality of life that are highly relevant...
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Potential role of skin microbiota in the pathogenesis of dermatological diseases
Mihula, Martin ; Jirásková Zákostelská, Zuzana (advisor) ; Grobárová, Valéria (referee)
The surface of the human body is colonized by a large number of microorganisms whose composition depends not only on external and internal factors, but is also significantly influenced by the topography of human skin. The complex skin microbiota is an essential part of physiological and protective mechanisms of the skin. The change in the dynamics of microbial communities on the skin or in the gastrointestinal tract is currently considered to be part of triggering mechanisms of many skin diseases. Some of the skin inflammatory diseases are directly associated with a shift of skin microbiota composition - for instance atopic dermatitis, acne vulgaris or psoriasis. Gaining and perceiving knowledge about interspecies interactions and their effect on a host could lead to the development of new diagnostic and therapeutic approaches which could make the prevention or treatment of some skin disorders more effective. Key words: skin, skin diseases, skin microbiota, immunity, psoriasis, atopic dermatitis, vitiligo
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Genetic of skin pigmentation disorders
ZLÁMALOVÁ, Aneta
Genetic skin disorders are one of the most common diseases. However, they may not be strictly related to skin diseases. There are many diseases that manifest on the skin, but from a diagnostic standpoint, they have nothing to do with the skin. This bachelor thesis deals with the skin and its most frequent diseases. Furthermore, related autoimmune diseases and genetics. Vitiligo is a disease that is associated with a melanocyte disorder in which pigment is formed and white spots appear on the skin. Morbus Darier is a skin disease characterized by warts on the body. Sores are usually yellowish in color, are touch sensitive, slightly oily and can produce a strong odor. In the methodological part, this bachelor thesis deals with the analysis of the FOXD3 gene for Vitiligo, which has one large exon and analysis of the twelfth exon in the ATP2A2 gene for Morbus Darier. Two probands were available for each disease. DNA analysis was used to analyze the sample, followed by PCR, Sanger sequencing and BioEdit and NCBI database evaluation. However, no mutation in any of the investigated sections was detected in either proband.
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In vitro testing of carrier system based on nanofibres for vitiligo treatment
Kodedová, Barbora ; Amler, Evžen (advisor) ; Kuželová Košťáková, Eva (referee)
Vitiligo is a skin disease with 2 % prevalence in a worldwide population. It is characterised by loss or decrease in activity of epidermal melanocytes, which lead to skin and hair depigmentation. It has negative impact on psyche, social relationships of patients and reduces the protection of the organism against UV radiation. One of the treatment methods is autologous transplantation of melanocytes or suspension of melanocytes with keratinocytes. Use of the biocompatible membrane, which allows the cultivation of these cells with resulting transplantation on the depigmented lesion, could improve treatment and make it more efficient. The main goal of this work was to create the biocompatible membrane from nanofiber layers of polyvinylalcohol (PVA) which can stand as a carrier for cell transplants in vitiligo therapy. PVA scaffolds were prepared by electrostatic spinning and later on modified by cold methane plasma (CH4) for lowering their hydrofility. Samples of modified nanofiber carriers were analysed according to their physical and chemical characteristics (visualization fiber morphology by SEM, XPS and surface Zeta potential analysis and contact angle). Consequently, adhesion, proliferation and metabolic activity of cultivating mice cell lines of melanocytes (Melan-a) and keratinocytes (XB2) were examined...
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The relation of the population's health condition and the system AB0.
Pavlíková, Zuzana ; Peterka, Miroslav (advisor) ; Likovský, Zbyněk (referee)
This work is a summary of observations about relationships between AB0 blood groups and occurrence of certain diseases. To diseases mentioned in this work belong different types of cancer, malaria, leprosy, small-pox, vitiligo and many others. Marked association with AB0 blood groups was found for cancer of stomach, ovarian cancer, peptic ulcers and cholera. The results for other diseases are not evident or on their relationship to blood groups were not made enough confirmative studies.
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Phototherapy
Joklík, Vojtěch ; Škoda, Jan (referee) ; Štěpánek, Jaroslav (advisor)
This thesis describes relationship between human body and light. It is focused on perception of light with human eye, skin and their reaction to incident light and its intensity. Then it contains short description of Icterus Neonatorum (yellow-gum), Constitutional Dermatitis, Lepriasis and their treatment. It is followed by description of various sources of light, their use in medicine and reaction of body to them. This work includes measurements and evaluation of five sources of light.
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Impact on life quality in patients with vitiligo
MALČICOVÁ, Jana
This bachelor thesis focuses on vitiligo and its impact on the life quality of patients suffering the disease. Vitiligo is a relatively frequent acquired disorder which causes depigmentation of parts of the skin. The depigmented spots can be of different shapes and extent. Vitiligo is a chronic disease process and the actual cause of the disease is still unknown. One of the presumable causes is the immune system; this is why it is not easily cured. The treatment is a long-term process and requires great patience from both the patient and the medical team. Vitiligo is a major problem for the patient as it disturbs their physical appearance and thus influences the psychological well being of the patient; so vitiligo can also have a psychosocial impact. In our research we set two main goals. The first of them was to define the role of nurses in the treatment of vitiligo. The other goal was to enquire about the impact of vitiligo on the life quality of the patients. For the research we formulated two questions: 1.What is the role of a nurse in the treatment of a vitiligo patient? 2. What is the impact of vitiligo on the life quality of the patient? For the empirical part of the bachelor thesis we used a qualitative research method based on a semi-structured interview. The first interrogated group consisted of four nurses from the South Bohemian and the South Moravian region; these nurses work in dermatology centres that offer phototherapeutic treatment. The other group comprised patients suffering vitiligo; we interviewed three patients from Austria and one patient from the Czech Republic. The respondents suffering from vitiligo were also to complete a Dermatological Index of Life Quality questionnaire. The questionnaire was then evaluated according to a key and the results were filled into a chart. The interviews consisted of 18 questions for the vitiligo patients and 10 questions for the caring nurses. The interviews were recorded on a dictaphone and later written down and brought into a Word document. For the evaluation of the data we used the open coding method using a pencil and paper. After the data analysis we defined the following categories: The Role of Nurses with the subcategory Alterations to the Role of Nurses, category Psychological Support with subcategories Attitude of Nurses, Psychical Needs of Patients, Alterations in Psychical Condition of the Patient, category Reaction to Detection of Vitiligo with the subcategories Reaction of the Patient, Reaction of Patient´s Environment, category Psychological Problems with the subcategories Patients´ Feelings and Solution to the Problems, category First Visit to the Doctor and category Significance of Vitiligo. The research suggests that the most important aspect of the nurses´ help during the patient´s treatment is the educational aspect. The other aspects are in the opinion of our respondents the health care providing aspect, and the help of a nurse as a manager. The evaluation of the life quality questionnaire brought the following results: two respondents saw only a small impact of the disease on their life quality. One respondent stated a slightly worsened quality of life and in one of the respondents the life quality was worsened significantly. According to the interviews, the vitiligo patients are slightly restrained during activities when exposed to sun due to an easy sunburnt. None of the respondents stated an influence on their relationships or hobbies. Two respondents mentioned worries concerning finding a partner and establishing a family. Our research showed that the greatest impact of vitiligo is on the psyche of the patient. Thus we assume that a psychological support should be an essential component of the treatment. I would like to present the results of this bachelor thesis as a review in some professional magazine. I would also be glad if the thesis could be an inspiration to a quantitative research on the topic.
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